| EC |
1.1.1.19 |
| Accepted name: |
glucuronate reductase |
| Reaction: |
L-gulonate + NADP+ = D-glucuronate + NADPH + H+ |
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For diagram of mammalian ascorbic-acid biosynthesis, click here |
| Other name(s): |
L-hexonate:NADP dehydrogenase; TPN-L-gulonate dehydrogenase; NADP-L-gulonate dehydrogenase; D-glucuronate dehydrogenase; D-glucuronate reductase; L-glucuronate reductase (incorrect) |
| Systematic name: |
L-gulonate:NADP+ 6-oxidoreductase |
| Comments: |
Also reduces D-galacturonate. May be identical with EC 1.1.1.2 [alcohol dehydrogenase (NADP+)]. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9028-29-9 |
| References: |
| 1. |
Sivak, A. and Hoffmann-Ostenhof, O. Enzymes of meso-inositol catabolism in the yeast Schwanniomyces occidentalis. Biochim. Biophys. Acta 53 (1961) 426–428. [DOI] [PMID: 13913518] |
| 2. |
von Wartburg, J.P. and Wermoth, B. Aldehyde reductase. In: Jakoby, W.B. (Ed.), Enzymatic Basis of Detoxication, vol. 1, Academic Press, New York, 1980, pp. 249–260. |
| 3. |
York, J.L., Grollman, A.P. and Bublitz, C. TPN-L-gulonate dehydrogenase. Biochim. Biophys. Acta 47 (1961) 298–306. [DOI] [PMID: 13787380] |
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| [EC 1.1.1.19 created 1961] |
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