ExplorEnz: EC 1.1.1.40

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1.1.1.40

Accepted name:

malate dehydrogenase (oxaloacetate-decarboxylating) (NADP⁺)

Reaction:

(1) (S)-malate + NADP⁺ = pyruvate + CO₂ + NADPH
(2) oxaloacetate = pyruvate + CO₂

Other name(s):

’malic’ enzyme (ambiguous); pyruvic-malic carboxylase (ambiguous); malate dehydrogenase (decarboxylating, NADP⁺); NADP⁺-linked decarboxylating malic enzyme; NADP⁺-malic enzyme; NADP⁺-specific malic enzyme; NADP⁺-specific malate dehydrogenase; malate dehydrogenase (NADP⁺, decarboxylating); L-malate:NADP⁺ oxidoreductase

Systematic name:

(S)-malate:NADP⁺ oxidoreductase (oxaloacetate-decarboxylating)

Comments:

The enzyme catalyses the oxidative decarboxylation of (S)-malate in the presence of NADP⁺ and divalent metal ions, and the decarboxylation of oxaloacetate. cf. EC 1.1.1.38, malate dehydrogenase (oxaloacetate-decarboxylating), and EC 1.1.1.39, malate dehydrogenase (decarboxylating).

Links to other databases:

BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9028-47-1

References:

1.	Harary, I., Korey, S.R. and Ochoa, S. Biosynthesis of dicarboxylic acids by carbon dioxide fixation. VII. Equilibrium of "malic" enzyme reaction. J. Biol. Chem. 203 (1953) 595–604. [PMID: 13084629]
2.	Ochoa, S., Mehler, A.H. and Kornberg, A. Biosynthesis of dicarboxylic acids by carbon dioxide fixation. I. Isolation and properties of an enzyme from pigeon liver catalyzing the reversible oxidative decarboxylation of l-malic acid. J. Biol. Chem. 174 (1948) 979–1000. [PMID: 18871257]
3.	Rutter, W.J. and Lardy, H.A. Purification and properties of pigeon liver malic enzyme. J. Biol. Chem. 233 (1958) 374–382. [PMID: 13563505]
4.	Stickland, R.G. Some properties of the malic enzyme of pigeon liver. 1. Conversion of malate into pyruvate. Biochem. J. 73 (1959) 646–654. [PMID: 13834656]
5.	Stickland, R.G. Some properties of the malic enzyme of pigeon liver. 2. Synthesis of malate from pyruvate. Biochem. J. 73 (1959) 654–659. [PMID: 13834657]
6.	Walker, D.A. Physiological studies on acid metabolism. 7. Malic enzyme from Kalanchoë crenata: effects of carbon dioxide concentration. Biochem. J. 74 (1960) 216–223. [PMID: 13842495]

[EC 1.1.1.40 created 1961, modified 1976]