EC |
1.1.1.40 |
Accepted name: |
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) |
Reaction: |
(1) (S)-malate + NADP+ = pyruvate + CO2 + NADPH (2) oxaloacetate = pyruvate + CO2 |
Other name(s): |
’malic’ enzyme (ambiguous); pyruvic-malic carboxylase (ambiguous); malate dehydrogenase (decarboxylating, NADP+); NADP+-linked decarboxylating malic enzyme; NADP+-malic enzyme; NADP+-specific malic enzyme; NADP+-specific malate dehydrogenase; malate dehydrogenase (NADP+, decarboxylating); L-malate:NADP+ oxidoreductase |
Systematic name: |
(S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating) |
Comments: |
The enzyme catalyses the oxidative decarboxylation of (S)-malate in the presence of NADP+ and divalent metal ions, and the decarboxylation of oxaloacetate. cf. EC 1.1.1.38, malate dehydrogenase (oxaloacetate-decarboxylating), and EC 1.1.1.39, malate dehydrogenase (decarboxylating). |
Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9028-47-1 |
References: |
1. |
Harary, I., Korey, S.R. and Ochoa, S. Biosynthesis of dicarboxylic acids by carbon dioxide fixation. VII. Equilibrium of "malic" enzyme reaction. J. Biol. Chem. 203 (1953) 595–604. [PMID: 13084629] |
2. |
Ochoa, S., Mehler, A.H. and Kornberg, A. Biosynthesis of dicarboxylic acids by carbon dioxide fixation. I. Isolation and properties of an enzyme from pigeon liver catalyzing the reversible oxidative decarboxylation of l-malic acid. J. Biol. Chem. 174 (1948) 979–1000. [PMID: 18871257] |
3. |
Rutter, W.J. and Lardy, H.A. Purification and properties of pigeon liver malic enzyme. J. Biol. Chem. 233 (1958) 374–382. [PMID: 13563505] |
4. |
Stickland, R.G. Some properties of the malic enzyme of pigeon liver. 1. Conversion of malate into pyruvate. Biochem. J. 73 (1959) 646–654. [PMID: 13834656] |
5. |
Stickland, R.G. Some properties of the malic enzyme of pigeon liver. 2. Synthesis of malate from pyruvate. Biochem. J. 73 (1959) 654–659. [PMID: 13834657] |
6. |
Walker, D.A. Physiological studies on acid metabolism. 7. Malic enzyme from KalanchoĆ« crenata: effects of carbon dioxide concentration. Biochem. J. 74 (1960) 216–223. [PMID: 13842495] |
|
[EC 1.1.1.40 created 1961, modified 1976] |
|
|
|
|