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Your query returned 1 entry. Printable version
EC | 1.1.1.85 | ||||||||
Accepted name: | 3-isopropylmalate dehydrogenase | ||||||||
Reaction: | (2R,3S)-3-isopropylmalate + NAD+ = 4-methyl-2-oxopentanoate + CO2 + NADH + H+ (overall reaction) (1a) (2R,3S)-3-isopropylmalate + NAD+ = (2S)-2-isopropyl-3-oxosuccinate + NADH + H+ (1b) (2S)-2-isopropyl-3-oxosuccinate = 4-methyl-2-oxopentanoate + CO2 (spontaneous) |
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For diagram of leucine biosynthesis, click here | |||||||||
Other name(s): | β-isopropylmalic enzyme; β-isopropylmalate dehydrogenase; threo-Ds-3-isopropylmalate dehydrogenase; 3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase | ||||||||
Systematic name: | (2R,3S)-3-isopropylmalate:NAD+ oxidoreductase | ||||||||
Comments: | The product decarboxylates spontaneously to yield 4-methyl-2-oxopentanoate. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9030-97-1 | ||||||||
References: |
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