EC |
1.14.11.11 |
Accepted name: |
hyoscyamine (6S)-dioxygenase |
Reaction: |
L-hyoscyamine + 2-oxoglutarate + O2 = (6S)-hydroxyhyoscyamine + succinate + CO2 |
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For diagram of tropane alkaloid biosynthesis, click here |
Other name(s): |
hyoscyamine 6β-hydroxylase; hyoscyamine 6β-dioxygenase; hyoscyamine 6-hydroxylase |
Systematic name: |
L-hyoscyamine,2-oxoglutarate:oxygen oxidoreductase [(6S)-hydroxylating] |
Comments: |
Requires Fe2+ and ascorbate. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 103865-33-4 |
References: |
1. |
Hashimoto, T. and Yamada, Y. Hyoscyamine 6β-hydroxylase, a 2-oxoglutarate-dependent dioxygenase, in alkaloid-producing root cultures. Plant Physiol. 81 (1986) 619–625. [PMID: 16664866] |
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[EC 1.14.11.11 created 1989] |
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