ExplorEnz: EC 1.3.1.126

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1.3.1.126

Accepted name:

2-epi-5-epi-valiolone dehydrogenase

Reaction:

2-epi-5-epi-valiolone + NAD⁺ = demethylgadusol + NADH + H⁺

Glossary:

2-epi-5-epi-valiolone = (2S,3S,4S,5R)-2,3,4,5-tetrahydroxy-5-(hydroxymethyl)cyclohexan-1-one
demethylgadusol = (4R,5R)-2,3,4,5-tetrahydroxy-5-(hydroxymethyl)cyclohex-2-en-1-one

Other name(s):

gadusol synthase

Systematic name:

2-epi-5-epi-valiolone:NAD⁺ 2,3-oxidoreductase

Comments:

The enzyme, present in egg-laying vertebrates, is involved in biosynthesis of the UV absorbing compound gadusol. It is a bifunctional enzyme that also catalyses EC 2.1.1.391, demethylgadusol O-methyltransferase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Osborn, A.R., Almabruk, K.H., Holzwarth, G., Asamizu, S., LaDu, J., Kean, K.M., Karplus, P.A., Tanguay, R.L., Bakalinsky, A.T. and Mahmud, T. De novo synthesis of a sunscreen compound in vertebrates. Elife 4 (2015) . [DOI] [PMID: 25965179]

[EC 1.3.1.126 created 2023]