EC |
1.5.1.5 |
Accepted name: |
methylenetetrahydrofolate dehydrogenase (NADP+) |
Reaction: |
5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH + H+ |
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For diagram of folate cofactors, click here and for diagram of C1 metabolism, click here |
Other name(s): |
N5,N10-methylenetetrahydrofolate dehydrogenase; 5,10-methylenetetrahydrofolate:NADP oxidoreductase; 5,10-methylenetetrahydrofolate dehydrogenase; methylenetetrahydrofolate dehydrogenase; methylenetetrahydrofolate dehydrogenase (NADP) |
Systematic name: |
5,10-methylenetetrahydrofolate:NADP+ oxidoreductase |
Comments: |
In eukaryotes, occurs as a trifunctional enzyme also having methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) and formate—tetrahydrofolate ligase (EC 6.3.4.3) activity. In some prokaryotes occurs as a bifunctional enzyme also having methenyltetrahydrofolate cyclohydrolase activity (EC 3.5.4.9). |
Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9029-14-5 |
References: |
1. |
Hatefi, Y., Osborn, M.J., Kay, L.D. and Huennekens, F.M. Hydroxymethyl tetrahydrofolic dehydrogenase. J. Biol. Chem. 227 (1957) 637–647. [PMID: 13462986] |
2. |
Osborn, M.J. and Huennekens, F.M. Participation of anhydroleucovorin in the hydroxymethyl tetrahydrofolic dehydrogenase system. Biochim. Biophys. Acta 26 (1957) 646–647. [DOI] [PMID: 13499428] |
3. |
Ramasastri, B.V. and Blakley, R.L. 5,10-Methylenetetrahydrofolic acid dehydrogenase from Bakers’ yeast. I. Partial purification and some properties. J. Biol. Chem. 237 (1962) 1982–1988. [PMID: 14490085] |
4. |
Yeh, Y.-C. and Greenberg, D.M. Purification and properties of N5,N10-methylenetetrahydrofolate dehydrogenase of calf thymus. Biochim. Biophys. Acta 105 (1965) 279–291. [PMID: 4379024] |
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[EC 1.5.1.5 created 1961] |
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