| EC |
2.1.1.215 |
| Accepted name: |
tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase |
| Reaction: |
4 S-adenosyl-L-methionine + guanine26/guanine27 in tRNA = 4 S-adenosyl-L-homocysteine + N2-dimethylguanine26/N2-dimethylguanine27 in tRNA |
| Other name(s): |
Trm1 (ambiguous); tRNA (N2,N2-guanine)-dimethyltransferase; tRNA (m2(2G26) methyltransferase; Trm1[tRNA (m2(2)G26) methyltransferase] |
| Systematic name: |
S-adenosyl-L-methionine:tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase |
| Comments: |
The enzyme from Aquifex aeolicus is similar to the TRM1 methyltransferases of archaea and eukarya (see EC 2.1.1.216, tRNA (guanine26-N2)-dimethyltransferase). However, it catalyses the double methylation of guanines at both positions 26 and 27 of tRNA. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Awai, T., Kimura, S., Tomikawa, C., Ochi, A., Ihsanawati, Bessho, Y., Yokoyama, S., Ohno, S., Nishikawa, K., Yokogawa, T., Suzuki, T. and Hori, H. Aquifex aeolicus tRNA (N2,N2-guanine)-dimethyltransferase (Trm1) catalyzes transfer of methyl groups not only to guanine 26 but also to guanine 27 in tRNA. J. Biol. Chem. 284 (2009) 20467–20478. [DOI] [PMID: 19491098] |
|
| [EC 2.1.1.215 created 2011 (EC 2.1.1.32 created 1972, part transferred 2011 to EC 2.1.1.215)] |
| |
|
| |
|
Printable version