| EC |
2.1.1.221 |
| Accepted name: |
tRNA (guanine9-N1)-methyltransferase |
| Reaction: |
S-adenosyl-L-methionine + guanine9 in tRNA = S-adenosyl-L-homocysteine + N1-methylguanine9 in tRNA |
| Other name(s): |
Trm10p (ambiguous); tRNA(m1G9/m1A9)-methyltransferase; tRNA(m1G9/m1A9)MTase; tRNA (guanine-N(1)-)-methyltransferase; tRNA m1G9-methyltransferase; tRNA m1G9 MTase |
| Systematic name: |
S-adenosyl-L-methionine:tRNA (guanine9-N1)-methyltransferase |
| Comments: |
The enzyme from Saccharomyces cerevisiae specifically methylates guanine9 [1,2]. The bifunctional enzyme from Thermococcus kodakaraensis also catalyses the methylation of adenine9 in tRNA (cf. EC 2.1.1.218, tRNA (adenine9-N1)-methyltransferase) [1]. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Kempenaers, M., Roovers, M., Oudjama, Y., Tkaczuk, K.L., Bujnicki, J.M. and Droogmans, L. New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA. Nucleic Acids Res. 38 (2010) 6533–6543. [DOI] [PMID: 20525789] |
| 2. |
Jackman, J.E., Montange, R.K., Malik, H.S. and Phizicky, E.M. Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9. RNA 9 (2003) 574–585. [DOI] [PMID: 12702816] |
|
| [EC 2.1.1.221 created 2011 (EC 2.1.1.31 created 1971, part transferred 2011 to EC 2.1.1.221)] |
| |
|
| |
|
Printable version