| EC |
2.1.1.388 |
| Accepted name: |
proline betaine—corrinoid protein Co-methyltransferase |
| Reaction: |
L-proline betaine + a [Co(I) quaternary-amine-specific corrinoid protein] = a [methyl-Co(III) quaternary-amine-specific corrinoid protein] + N-methyl-L-proline |
| Glossary: |
L-proline betaine = (2S)-1,1-dimethylpyrrolidinium-2-carboxylate |
| Other name(s): |
mtpB (gene name) |
| Systematic name: |
L-proline betaine:[Co(I) quaternary-amine-specific corrinoid protein] Co-methyltransferase |
| Comments: |
The enzyme, characterized from the bacterium Eubacterium limosum, is a component of a system that transfers a methyl group from L-proline betaine to tetrahydrofolate, as part of an L-proline betaine degradation pathway. The resulting 5-methyltetrahydrofolate is processed to acetyl-CoA via the Wood—Ljungdahl pathway. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Picking, J.W., Behrman, E.J., Zhang, L. and Krzycki, J.A. MtpB, a member of the MttB superfamily from the human intestinal acetogen Eubacterium limosum, catalyzes proline betaine demethylation. J. Biol. Chem. 294 (2019) 13697–13707. [DOI] [PMID: 31341018] |
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| [EC 2.1.1.388 created 2023] |
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