| EC |
2.3.1.186 |
| Accepted name: |
pseudotropine acyltransferase |
| Reaction: |
an acyl-CoA + pseudotropine = CoA + an O-acylpseudotropine |
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For diagram of tropane alkaloid biosynthesis, click here |
| Glossary: |
tropine = tropan-3β-ol = 3β-hydroxytropane |
| Other name(s): |
pseudotropine:acyl-CoA transferase; tigloyl-CoA:pseudotropine acyltransferase; acetyl-CoA:pseudotropine acyltransferase; pseudotropine acetyltransferase; pseudotropine tigloyltransferase; PAT (ambiguous) |
| Systematic name: |
acyl-CoA:pseudotropine O-acyltransferase |
| Comments: |
This enzyme exhibits absolute specificity for the exo/3β configuration found in pseudotropine as tropine (tropan-3α-ol; see EC 2.3.1.185, tropine acyltransferase) and nortropine are not substrates [1]. Acts on a wide range of aliphatic acyl-CoA derivatives, including acetyl-CoA, β-methylcrotonyl-CoA and tigloyl-CoA [1]. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 138440-78-5, 162535-26-4 |
| References: |
| 1. |
Rabot, S., Peerless, A.C.J. and Robins, R.J. Tigloyl-CoA:pseudotropine acyltransferase — an enzyme of tropane alkaloid biosynthesis. Phytochemistry 39 (1995) 315–322. |
| 2. |
Robins, R.J., Bachmann, P., Robinson, T., Rhodes, M.J. and Yamada, Y. The formation of 3α- and 3β-acetoxytropanes by Datura stramonium transformed root cultures involves two acetyl-CoA-dependent acyltransferases. FEBS Lett. 292 (1991) 293–297. [DOI] [PMID: 1959620] |
| 3. |
Robins, R.J., Bachmann,P., Peerless, A.C.J. and Rabot, S. Esterification reactions in the biosynthesis of tropane alkaloids in transformed root cultures. Plant Cell, Tissue Organ Cult. 38 (1994) 241–247. |
| 4. |
Boswell, H.D., Dräger, B., McLauchlan, W.R., Portsteffen, A., Robins, D.J., Robins, R.J. and Walton, N.J. Specificities of the enzymes of N-alkyltropane biosynthesis in Brugmansia and Datura. Phytochemistry 52 (1999) 871–878. [DOI] [PMID: 10626376] |
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| [EC 2.3.1.186 created 2008] |
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