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Your query returned 1 entry. Printable version
EC | 2.4.99.20 | ||||
Accepted name: | 2′-phospho-ADP-ribosyl cyclase/2′-phospho-cyclic-ADP-ribose transferase | ||||
Reaction: | NADP+ + nicotinate = nicotinate-adenine dinucleotide phosphate + nicotinamide (overall reaction) (1a) NADP+ = 2′-phospho-cyclic ADP-ribose + nicotinamide (1b) 2′-phospho-cyclic ADP-ribose + nicotinate = nicotinate-adenine dinucleotide phosphate |
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For diagram of cyclic ADP-ribose biosynthesis, click here | |||||
Glossary: | 2′-phospho-cyclic ADP-ribose = cADPRP nicotinic acid-adenine dinucleotide phosphate = NAADP+ |
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Other name(s): | diphosphopyridine nucleosidase (ambiguous); CD38 (gene name); BST1 (gene name) | ||||
Systematic name: | NADP+:nicotinate ADP-ribosyltransferase | ||||
Comments: | This multiunctional enzyme catalyses both the removal of nicotinamide from NADP+, forming 2′-phospho-cyclic ADP-ribose, and the addition of nicotinate to the cyclic product, forming NAADP+, a calcium messenger that can mobilize intracellular Ca2+ stores and activate Ca2+ influx to regulate a wide range of physiological processes. In addition, the enzyme also catalyses EC 3.2.2.6, ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||
References: |
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