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Your query returned 1 entry. 
Printable version
| EC | 2.6.1.85 | ||||||||
| Accepted name: | aminodeoxychorismate synthase | ||||||||
| Reaction: | chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate (overall reaction) (1a) L-glutamine + H2O = L-glutamate + NH3 (1b) chorismate + NH3 = 4-amino-4-deoxychorismate + H2O |
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| For diagram of folate biosynthesis (late stages), click here | |||||||||
| Other name(s): | ADC synthase; 4-amino-4-deoxychorismate synthase; PabAB; chorismate:L-glutamine amido-ligase (incorrect) | ||||||||
| Systematic name: | chorismate:L-glutamine aminotransferase | ||||||||
| Comments: | The enzyme is composed of two parts, a glutaminase (PabA in Escherichia coli) and an aminotransferase (PabB). In the absence of PabA and glutamine (but in the presence of Mg2+), PabB can convert ammonia and chorismate into 4-amino-4-deoxychorismate. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB. In many organisms, including plants, the genes encoding the two proteins have fused to encode a single bifunctional protein. This enzyme is coupled with EC 4.1.3.38, aminodeoxychorismate lyase, to form 4-aminobenzoate. cf. EC 2.6.1.123, 4-amino-4-deoxychorismate synthase (2-amino-4-deoxychorismate-forming). | ||||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||
| References: |
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