| EC |
2.7.7.13 |
| Accepted name: |
mannose-1-phosphate guanylyltransferase |
| Reaction: |
GTP + α-D-mannose 1-phosphate = diphosphate + GDP-mannose |
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For diagram of GDP-L-fucose and GDP-mannose biosynthesis, click here |
| Other name(s): |
GTP-mannose-1-phosphate guanylyltransferase; PIM-GMP (phosphomannose isomerase-guanosine 5′-diphospho-D-mannose pyrophosphorylase); GDP-mannose pyrophosphorylase; guanosine 5′-diphospho-D-mannose pyrophosphorylase; guanosine diphosphomannose pyrophosphorylase; guanosine triphosphate-mannose 1-phosphate guanylyltransferase; mannose 1-phosphate guanylyltransferase (guanosine triphosphate) |
| Systematic name: |
GTP:α-D-mannose-1-phosphate guanylyltransferase |
| Comments: |
The bacterial enzyme can also use ITP and dGTP as donors. |
| Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 37278-24-3 |
| References: |
| 1. |
Munch-Peterson, A. Enzymatic synthesis and phosphorolysis of guanosine diphosphate mannose. Arch. Biochem. Biophys. 55 (1955) 592–593. |
| 2. |
Preiss, J. and Wood, E. Sugar nucleotide reactions in Arthrobacter. I. Guanosinediphosphate mannose pyrophosphorylase: purification and properties. J. Biol. Chem. 239 (1964) 3119–3126. [PMID: 14245350] |
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| [EC 2.7.7.13 created 1961, modified 1976] |
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