| EC |
2.7.7.49 |
| Accepted name: |
RNA-directed DNA polymerase |
| Reaction: |
a 2′-deoxyribonucleoside 5′-triphosphate + DNAn = diphosphate + DNAn+1 |
| Other name(s): |
DNA nucleotidyltransferase (RNA-directed); reverse transcriptase; revertase; RNA-dependent deoxyribonucleate nucleotidyltransferase; RNA revertase; RNA-dependent DNA polymerase; RNA-instructed DNA polymerase; RT |
| Systematic name: |
2′-deoxyribonucleoside-5′-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) |
| Comments: |
Catalyses RNA-template-directed extension of the 3′- end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo. Requires an RNA or DNA primer. DNA can also serve as template. See also EC 2.7.7.7 DNA-directed DNA polymerase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9068-38-6 |
| References: |
| 1. |
Baltimore, D. RNA-dependent DNA polymerase in virions of RNA tumour viruses. Nature 226 (1970) 1209–1211. [PMID: 4316300] |
| 2. |
Temin, H. and Mizutani, S. RNA-dependent DNA polymerase in virions of Rous sarcoma virus. Nature 226 (1970) 1211–1213. [PMID: 4316301] |
|
| [EC 2.7.7.49 created 1981, modified 1982] |
| |
|
| |
|
Printable version