ExplorEnz: EC 3.1.3.110

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3.1.3.110

Accepted name:

4′-phosphopantetheine phosphatase

Reaction:

4′-phosphopantetheine + H₂O = pantetheine + phosphate

Glossary:

pantetheine = (2R)-2,4-dihydroxy-3,3-dimethyl-N-{3-oxo-3-[(2-sulfanylethyl)amino]propyl}butanamide

Other name(s):

thnH (gene name); PANK4 (gene name)

Systematic name:

4′-phosphopantetheine phosphohydrolase

Comments:

The enzyme has been characterized from mammals and from the bacterium Streptantibioticus cattleyicolor. In mammals it hydrolyses excess 4′-phosphopantetheine to prevent cell damage. In S. cattleyicolor it participates in the biosynthesis of the β-lactam antibiotic thienamycin.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

Freeman, M.F., Moshos, K.A., Bodner, M.J., Li, R. and Townsend, C.A. Four enzymes define the incorporation of coenzyme A in thienamycin biosynthesis. Proc. Natl. Acad. Sci. USA 105 (2008) 11128–11133. [DOI] [PMID: 18678912]

Huang, L., Khusnutdinova, A., Nocek, B., Brown, G., Xu, X., Cui, H., Petit, P., Flick, R., Zallot, R., Balmant, K., Ziemak, M.J., Shanklin, J., de Crecy-Lagard, V., Fiehn, O., Gregory, J.F., 3rd, Joachimiak, A., Savchenko, A., Yakunin, A.F. and Hanson, A.D. A family of metal-dependent phosphatases implicated in metabolite damage-control. Nat. Chem. Biol. 12 (2016) 621–627. [DOI] [PMID: 27322068]

[EC 3.1.3.110 created 2024]