| EC |
3.5.99.16 |
| Accepted name: |
deacetylipecoside synthase |
| Reaction: |
deacetylipecoside + H2O = dopamine + secologanin |
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For diagram of indole and ipecac alkaloid biosynthesis, click here |
| Glossary: |
dopamine = 4-(2-aminoethyl)benzene-1,2-diol |
| Other name(s): |
deacetylipecoside dopamine-lyase; deacetylipecoside dopamine-lyase (secologanin-forming) |
| Systematic name: |
deacetylipecoside dopamine-hydroyase (secologanin-forming) |
| Comments: |
The enzyme from the leaves of Alangium lamarckii differs in enantiomeric specificity from EC 3.5.99.15, deacetylisoipecoside synthase. The product is rapidly converted to demethylalangiside. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 192827-93-3 |
| References: |
| 1. |
DeEknamkul, W., Ounaroon, A., Tanahashi, T., Kutchan, T. and Zenk, M.H. Enzymatic condensation of dopamine and secologanin by cell-free extracts of Alangium lamarckii. Phytochemistry 45 (1997) 477–484. [DOI] |
| 2. |
De-Eknamkul, W., Suttipanta, N. and Kutchan, T.M. Purification and characterization of deacetylipecoside synthase from Alangium lamarckii Thw. Phytochemistry 55 (2000) 177–181. [DOI] [PMID: 11065292] |
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| [EC 3.5.99.16 created 2000 as EC 4.3.3.4, transferred 2024 to EC 3.5.99.16] |
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