ExplorEnz: EC 4.1.1.126

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4.1.1.126

Accepted name:

anhydromevalonate phosphate decarboxylase

Reaction:

trans-anhydromevalonate 5-phosphate = 3-methylbut-3-en-1-yl phosphate + CO₂

Glossary:

trans-anhydromevalonate 5-phosphate = (2E)-3-methyl-5-phosphooxypent-2-enoate
3-methylbut-3-en-1-yl phosphate = isopentenyl phosphate

Systematic name:

trans-anhydromevalonate 5-phosphate carboxy-lyase

Comments:

The enzyme catalyses a step in the archaeal prenyl diphosphate biosynthesis pathway. It requires a prenylated flavin cofactor that is produced by EC 2.5.1.129, flavin prenyltransferase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Yoshida, R., Yoshimura, T. and Hemmi, H. Reconstruction of the "archaeal" mevalonate pathway from the methanogenic archaeon Methanosarcina mazei in Escherichia coli cells. Appl. Environ. Microbiol. 86:e02889-19 (2020). [DOI] [PMID: 31924615]

[EC 4.1.1.126 created 2023]