| EC |
4.1.3.16 |
| Accepted name: |
4-hydroxy-2-oxoglutarate aldolase |
| Reaction: |
4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate |
| Other name(s): |
2-oxo-4-hydroxyglutarate aldolase; hydroxyketoglutaric aldolase; 4-hydroxy-2-ketoglutaric aldolase; 2-keto-4-hydroxyglutaric aldolase; 4-hydroxy-2-ketoglutarate aldolase; 2-keto-4-hydroxyglutarate aldolase; 2-oxo-4-hydroxyglutaric aldolase; DL-4-hydroxy-2-ketoglutarate aldolase; hydroxyketoglutarate aldolase; 2-keto-4-hydroxybutyrate aldolase; 4-hydroxy-2-oxoglutarate glyoxylate-lyase; KHGA |
| Systematic name: |
4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming) |
| Comments: |
The enzymes from rat liver and bovine liver act on both enantiomers of 4-hydroxy-2-oxoglutarate. cf. EC 4.1.3.42, (4S)-4-hydroxy-2-oxoglutarate aldolase. |
| Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9030-81-3 |
| References: |
| 1. |
Kuratomi, K. and Fukunaga, K. The metabolism of γ-hydroxyglutamate in rat liver. I. Enzymic synthesis of γ-hydroxy-α-ketoglutarate from pyruvate and glyoxalate. Biochim. Biophys. Acta 78 (1963) 617–628. [DOI] [PMID: 14089442] |
| 2. |
Kobes, R.D. and Dekker, E.E. 2-Keto-4-hydroxyglutarate aldolase of bovine liver. Purification, criteria of purity, and general properties. J. Biol. Chem. 244 (1969) 1919–1925. [PMID: 5780845] |
| 3. |
Lane, R.S., Shapley, A. and Dekker, E.E. 2-keto-4-hydroxybutyrate aldolase. Identification as 2-keto-4-hydroxyglutarate aldolase, catalytic properties, and role in the mammalian metabolism of L-homoserine. Biochemistry 10 (1971) 1353–1364. [PMID: 5580656] |
| 4. |
Scholtz, J.M. and Schuster, S.M. Regulation of rat liver 4-hydroxy-2-ketoglutarate aldolase. Biochim. Biophys. Acta 869 (1986) 192–196. [DOI] [PMID: 3942759] |
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| [EC 4.1.3.16 created 1972 (EC 4.1.2.1 created 1961, incorporated 1972, EC 4.1.2.31 created 1978, incorporated 1982)] |
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