EC |
4.2.1.182 |
Accepted name: |
phosphomevalonate dehydratase |
Reaction: |
(R)-5-phosphomevalonate = trans-anhydromevalonate 5-phosphate + H2O |
Glossary: |
trans-anhydromevalonate 5-phosphate = (2E)-3-methyl-5-phosphooxypent-2-enoate |
Systematic name: |
R-5-phosphomevalonate hydro-lyase |
Comments: |
The enzyme catalyses a step in an archaeal prenyl diphosphate biosynthesis pathway. It belongs to the aconitase X family, and contains a [4Fe-4S] cluster. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Yoshida, R., Yoshimura, T. and Hemmi, H. Reconstruction of the "archaeal" mevalonate pathway from the methanogenic archaeon Methanosarcina mazei in Escherichia coli cells. Appl. Environ. Microbiol. 86:e02889-19 (2020). [DOI] [PMID: 31924615] |
2. |
Komeyama, M., Kanno, K., Mino, H., Yasuno, Y., Shinada, T., Ito, T. and Hemmi, H. A [4Fe-4S] cluster resides at the active center of phosphomevalonate dehydratase, a key enzyme in the archaeal modified mevalonate pathway. Front Microbiol. 14:1150353 (2023). [DOI] [PMID: 36992929] |
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[EC 4.2.1.182 created 2023] |
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