| EC |
4.2.3.202 |
| Accepted name: |
hydropyrenol synthase |
| Reaction: |
geranylgeranyl diphosphate + H2O = hydropyrenol + diphosphate |
| Glossary: |
hydropyrenol = (1R,3aR,3a1S,4S,5aR,5a1S,8aS,10aS)-1,4,5a,8a-tetramethylhexadecahydropyren-4-ol |
| Other name(s): |
HpS |
| Systematic name: |
geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, hydropyrenol-forming) |
| Comments: |
Isolated from the bacterium Streptomyces clavuligerus. The 1-proR hydrogen atom of geranylgeranyl diphosphate is lost in the reaction. The enzyme also produces hydropyrene, isoelisabethatriene and traces of other diterpenoids. cf. EC 4.2.3.201, hydropyrene synthase, and EC 4.2.3.203, isoelisabethatriene synthase. |
| References: |
| 1. |
Rinkel, J., Rabe, P., Chen, X., Kollner, T.G., Chen, F. and Dickschat, J.S. Mechanisms of the diterpene cyclases β-pinacene synthase from Dictyostelium discoideum and hydropyrene synthase from Streptomyces clavuligerus. Chem. Eur. J. 23 (2017) 10501–10505. [PMID: 28696553] |
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| [EC 4.2.3.202 created 2019] |
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