ExplorEnz: EC 4.3.1.33

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4.3.1.33

Accepted name:

(R)-1-hydroxy-2-aminoethylphosphonate ammonia-lyase

Reaction:

(1R)-(2-amino-1-hydroxyethyl)phosphonate = phosphonoacetaldehyde + NH₃ (overall reaction)
(1a) (1R)-(2-amino-1-hydroxyethyl)phosphonate = (E)-2-aminoethenylphosphonate + H₂O
(1b) (E)-2-aminoethenylphosphonate + H₂O = phosphonoacetaldehyde + NH₃

Glossary:

phosphonoacetaldehyde = (2-oxoethyl)phosphonate

Other name(s):

pbfA (gene name)

Systematic name:

(1R)-(2-amino-1-hydroxyethyl)phosphonate ammonia-lyase

Comments:

A pyridoxal 5′-phosphate enzyme. This bacterial enzyme, characterized from the marine bacterium Vibrio splendidus, expands the substrate scope of a widespread pathway for the degradation of 2-aminoethylphosphonate. The enzyme is highly specific and does not act on the S enantiomer of 1-hydroxy-2-aminoethylphosphonate or other structurally related compounds.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Zangelmi, E., Stankovic, T., Malatesta, M., Acquotti, D., Pallitsch, K. and Peracchi, A. Discovery of a new, recurrent enzyme in bacterial phosphonate degradation: (R)-1-hydroxy-2-aminoethylphosphonate ammonia-lyase. Biochemistry 60 (2021) 1214–1225. [DOI] [PMID: 33830741]

[EC 4.3.1.33 created 2023]