| EC |
6.3.4.5 |
| Accepted name: |
argininosuccinate synthase |
| Reaction: |
ATP + L-citrulline + L-aspartate = AMP + diphosphate + 2-(Nω-L-arginino)succinate |
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For diagram of the urea cycle and arginine biosynthesis, click here |
| Other name(s): |
citrulline—aspartate ligase; argininosuccinate synthetase; arginine succinate synthetase; argininosuccinic acid synthetase; arginosuccinate synthetase |
| Systematic name: |
L-citrulline:L-aspartate ligase (AMP-forming) |
| Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9023-58-9 |
| References: |
| 1. |
Ratner, S. Urea synthesis and metabolism of arginine and citrulline. Adv. Enzymol. Relat. Subj. Biochem. 15 (1954) 319–387. [PMID: 13158183] |
| 2. |
Schuegraf, A., Ratner, S. and Warner, R.C. Free energy changes of the argininosuccinate synthetase reaction and of the hydrolysis of the inner pyrophosphate bond of adenosine triphosphate. J. Biol. Chem. 235 (1960) 3597–3602. [PMID: 13748745] |
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| [EC 6.3.4.5 created 1961] |
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