EC |
1.2.1.107 |
Accepted name: |
glyceraldehyde-3-phosphate dehydrogenase (arsenate-transferring) |
Reaction: |
D-glyceraldehyde 3-phosphate + arsenate + NAD+ = 1-arsono-3-phospho-D-glycerate + NADH + H+ |
Glossary: |
1-arsono-3-phosphoglycerate = [(2R)-2-hydroxy-3-phosphopropanoyl]oxyarsonate |
Systematic name: |
D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (arsenate-transferring) |
Comments: |
The enzyme, discovered in bacteria, is very similar to EC 1.2.1.12, glyceraldehyde-3-phosphate dehydrogenase (phosphorylating). However, the gene encoding it is located in arsenic resistance islands in the chromosome, next to a gene (arsJ) that encodes a transporter that removes the product, 1-arsono-3-phosphoglycerate, from the cell. Together the two proteins form an arsenic detoxification system. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Chen, J., Yoshinaga, M., Garbinski, L.D. and Rosen, B.P. Synergistic interaction of glyceraldehydes-3-phosphate dehydrogenase and ArsJ, a novel organoarsenical efflux permease, confers arsenate resistance. Mol. Microbiol. 100 (2016) 945–953. [DOI] [PMID: 26991003] |
2. |
Wu, S., Wang, L., Gan, R., Tong, T., Bian, H., Li, Z., Du, S., Deng, Z. and Chen, S. Signature arsenic detoxification pathways in Halomonas sp. strain GFAJ-1. mBio 9 (2018) . [DOI] [PMID: 29717010] |
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[EC 1.2.1.107 created 2021] |
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