EC |
1.1.1.434 |
Accepted name: |
2-dehydro-3-deoxy-L-fuconate 4-dehydrogenase |
Reaction: |
2-dehydro-3-deoxy-L-fuconate + NAD+ = 2,4-didehydro-3-deoxy-L-fuconate + NADH + H+ |
Glossary: |
2-dehydro-3-deoxy-L-fuconate = (4S,5S)-4,5-dihydroxy-2-oxohexanoate
2,4-didehydro-3-deoxy-L-fuconate = (5S)-5-hydroxy-2,4-dioxohexanoate |
Systematic name: |
2-dehydro-3-deoxy-L-fuconate:NAD+ 4-oxidoreductase |
Comments: |
The enzyme, originally described from the bacterium Xanthomonas campestris pv. campestris, participates in an L-fucose degradation pathway. It can also act on 2-dehydro-3-deoxy-L-galactonate and 2-dehydro-3-deoxy-D-pentonate. |
References: |
1. |
Yew, W.S., Fedorov, A.A., Fedorov, E.V., Rakus, J.F., Pierce, R.W., Almo, S.C. and Gerlt, J.A. Evolution of enzymatic activities in the enolase superfamily: L-fuconate dehydratase from Xanthomonas campestris. Biochemistry 45 (2006) 14582–14597. [PMID: 17144652] |
2. |
Watanabe, S., Fukumori, F., Nishiwaki, H., Sakurai, Y., Tajima, K. and Watanabe, Y. Novel non-phosphorylative pathway of pentose metabolism from bacteria. Sci. Rep. 9:155 (2019). [PMID: 30655589] |
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[EC 1.1.1.434 created 2022] |
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EC |
4.1.2.64 |
Accepted name: |
2-dehydro-3-deoxy-L-fuconate aldolase |
Reaction: |
2-dehydro-3-deoxy-L-fuconate = pyruvate + (S)-lactaldehyde |
Other name(s): |
2-keto-3-deoxy-L-fuconate aldolase; L-2-keto-3-deoxyfuconate aldolase; fucH (gene name) |
Systematic name: |
2-dehydro-3-deoxy-L-fuconate (S)-lactaldehyde-lyase (pyruvate-forming) |
Comments: |
The enzyme, characterized from the bacteria Veillonella ratti and Campylobacter jejuni, participates in an L-fucose degradation pathway. It also has significant activity with 2-dehydro-3-deoxy-D-pentonate (cf. EC 4.1.2.28, 2-dehydro-3-deoxy-D-pentonate aldolase). |
References: |
1. |
Watanabe, S. Characterization of L-2-keto-3-deoxyfuconate aldolases in a nonphosphorylating L-fucose metabolism pathway in anaerobic bacteria. J. Biol. Chem. 295 (2020) 1338–1349. [PMID: 31914410] |
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[EC 4.1.2.64 created 2023] |
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EC |
4.2.1.68 |
Accepted name: |
L-fuconate dehydratase |
Reaction: |
L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H2O |
Other name(s): |
L-fuconate hydro-lyase |
Systematic name: |
L-fuconate hydro-lyase (2-dehydro-3-deoxy-L-fuconate-forming) |
Comments: |
Also acts, slowly, on D-arabinonate. |
References: |
1. |
Yuen, R. and Schachter, H. L-Fucose metabolism in mammals. I. Pork liver L-fuconate hydro-lyase. Can. J. Biochem. 50 (1972) 798–806. [PMID: 5050937] |
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[EC 4.2.1.68 created 1976] |
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