EC |
1.13.11.83 |
Accepted name: |
4-hydroxy-3-prenylphenylpyruvate oxygenase |
Reaction: |
3-(4-hydroxy-3-prenylphenyl)pyruvate + O2 = 4-hydroxy-3-prenylmandelate + CO2 |
Glossary: |
3-(4-hydroxy-3-prenylphenyl)pyruvate = 3-(4-hydroxy-3-prenylphenyl)-2-oxopropanoate
4-hydroxy-3-prenylmandelate = 2-hydroxy-2-(4-hydroxy-3-prenylphenyl)acetate
prenyl = 3-methylbut-2-en-1-yl |
Other name(s): |
CloR |
Systematic name: |
3-(4-hydroxy-3-prenylphenyl)pyruvate:oxygen 1,2-oxidoreductase (4-hydroxy-3-prenylmandelate-forming) |
Comments: |
Requires non-heme-iron(II). Isolated from the bacterium Streptomyces roseochromogenes DS 12976. A bifunctional enzyme involved in clorobiocin biosynthesis that also catalyses the activity of EC 1.13.12.23, 4-hydroxy-3-prenylbenzoate synthase. |
References: |
1. |
Pojer, F., Kahlich, R., Kammerer, B., Li, S.M. and Heide, L. CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis. J. Biol. Chem. 278 (2003) 30661–30668. [PMID: 12777382] |
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[EC 1.13.11.83 created 2017] |
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EC |
1.13.12.23 |
Accepted name: |
4-hydroxy-3-prenylbenzoate synthase |
Reaction: |
4-hydroxy-3-prenylmandelate + O2 = 4-hydroxy-3-prenylbenzoate + CO2 + H2O |
Glossary: |
4-hydroxy-3-prenylmandelate = 2-hydroxy-2-(4-hydroxy-3-prenylphenyl)acetate
prenyl = 3-methylbut-2-en-1-yl |
Other name(s): |
CloR; novR (gene name) |
Systematic name: |
4-hydroxy-3-prenylmandelate:oxygen oxidoreductase (4-hydroxy-3-prenylbenzoate forming) |
Comments: |
Isolated from the bacterium Streptomyces roseochromogenes DS 12976. A bifunctional enzyme involved in clorobiocin biosynthesis that also catalyses the activity of EC 1.13.11.83, 4-hydroxy-3-prenylphenylpyruvate oxygenase. |
References: |
1. |
Pojer, F., Kahlich, R., Kammerer, B., Li, S.M. and Heide, L. CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis. J. Biol. Chem. 278 (2003) 30661–30668. [PMID: 12777382] |
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[EC 1.13.12.23 created 2017] |
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