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Your query returned 2 entries. Printable version
EC | 1.8.1.12 | ||||||||||
Accepted name: | trypanothione-disulfide reductase | ||||||||||
Reaction: | trypanothione + NADP+ = trypanothione disulfide + NADPH + H+ | ||||||||||
For diagram of trypanothione biosynthesis, click here | |||||||||||
Glossary: | spermidine = N-(3-aminopropyl)butane-1,4-diamine trypanothione = N1,N8-bis(glutathionyl)spermidine |
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Other name(s): | trypanothione reductase; NADPH2:trypanothione oxidoreductase | ||||||||||
Systematic name: | trypanothione:NADP+ oxidoreductase | ||||||||||
Comments: | Trypanothione disulfide is the oxidized form of N1,N8-bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata. The enzyme from Crithidia fasciculata is a flavoprotein (FAD), whose activity is dependent on a redox-active cystine at the active centre. (cf. EC 1.8.1.7, glutathione-disulfide reductase) | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 102210-35-5 | ||||||||||
References: |
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EC | 6.3.1.9 | ||||||||||
Accepted name: | trypanothione synthase | ||||||||||
Reaction: | (1) glutathione + spermidine + ATP = glutathionylspermidine + ADP + phosphate (2) glutathione + glutathionylspermidine + ATP = N1,N8-bis(glutathionyl)spermidine + ADP + phosphate |
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For diagram of trypanothione biosynthesis, click here and for diagram of trypanothione biosynthesis, click here | |||||||||||
Glossary: | N1,N8-bis(glutathionyl)spermidine = trypanothione | ||||||||||
Other name(s): | glutathionylspermidine:glutathione ligase (ADP-forming) | ||||||||||
Systematic name: | spermidine/glutathionylspermidine:glutathione ligase (ADP-forming) | ||||||||||
Comments: | The enzyme, characterized from several trypanosomatids (e.g. Trypanosoma cruzi) catalyses two subsequent reactions, leading to production of trypanothione from glutathione and spermidine. Some trypanosomatids (e.g. Crithidia species and some Leishmania species) also contain an enzyme that only carries out the first reaction (cf. EC 6.3.1.8, glutathionylspermidine synthase). The enzyme is bifunctional, and also catalyses the hydrolysis of glutathionylspermidine and trypanothione (cf. EC 3.5.1.78, glutathionylspermidine amidase). | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 130246-69-4 | ||||||||||
References: |
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