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Your query returned 11 entries. Printable version
EC | 1.3.1.84 | ||||||||||
Accepted name: | acrylyl-CoA reductase (NADPH) | ||||||||||
Reaction: | propanoyl-CoA + NADP+ = acryloyl-CoA + NADPH + H+ | ||||||||||
For diagram of the 3-hydroxypropanoate cycle, click here, for diagram of the 3-hydroxypropanoate/4-hydroxybutanoate cycle and dicarboxylate/4-hydroxybutanoate cycle in archaea, click here and for diagram of 3-(dimethylsulfonio)propanoate met | |||||||||||
Glossary: | propanoyl-CoA = propionyl-CoA acryloyl-CoA = acrylyl-CoA = propenoyl-CoA |
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Systematic name: | propanoyl-CoA:NADP+ oxidoreductase | ||||||||||
Comments: | Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1]. The enzyme from Sulfolobus tokodaii does not act on either NADH or crotonyl-CoA [2]. Different from EC 1.3.1.8, which acts only on enoyl-CoA derivatives of carbon chain length 4 to 16. Contains Zn2+. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||
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EC | 1.3.1.95 | ||||||||||
Accepted name: | acrylyl-CoA reductase (NADH) | ||||||||||
Reaction: | propanoyl-CoA + NAD+ = acryloyl-CoA + NADH + H+ | ||||||||||
For diagram of 3-(dimethylsulfonio)propanoate metabolism, click here | |||||||||||
Glossary: | propanoyl-CoA = propionyl-CoA | ||||||||||
Systematic name: | propanoyl-CoA:NAD+ oxidoreductase | ||||||||||
Comments: | Contains FAD. The reaction is catalysed in the opposite direction to that shown. The enzyme from the bacterium Clostridium propionicum is a complex that includes an electron-transfer flavoprotein (ETF). The ETF is reduced by NADH and transfers the electrons to the active site. Catalyses a step in a pathway for L-alanine fermentation to propanoate [1]. cf. EC 1.3.1.84, acrylyl-CoA reductase (NADPH). | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||
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EC | 1.3.1.108 | ||||||||||
Accepted name: | caffeoyl-CoA reductase | ||||||||||
Reaction: | 3-(3,4-dihydroxyphenyl)propanoyl-CoA + 2 NAD+ + 2 reduced ferredoxin [iron-sulfur] cluster = (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl-CoA + 2 NADH + 2 oxidized ferredoxin [iron-sulfur] cluster | ||||||||||
Glossary: | (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl-CoA = (2E)-3-(3,4-dihydroxyphenyl)acryloyl-CoA = trans-caffeoyl-CoA 3-(3,4-dihydroxyphenyl)propanoyl-CoA = hydrocaffeoyl-CoA |
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Other name(s): | electron-bifurcating caffeoyl-CoA reductase; caffeoyl-CoA reductase-Etf complex; hydrocaffeoyl-CoA:NAD+,ferredoxin oxidoreductase | ||||||||||
Systematic name: | 3-(3,4-dihydroxyphenyl)propanoyl-CoA:NAD+,ferredoxin oxidoreductase | ||||||||||
Comments: | The enzyme, characterized from the bacterium Acetobacterium woodii, contains two [4Fe-4S] clusters and FAD. The enzyme couples the endergonic ferredoxin reduction with NADH as reductant to the exergonic reduction of caffeoyl-CoA with the same reductant. It uses the mechanism of electron bifurcation to overcome the steep energy barrier in ferredoxin reduction. It also reduces 4-coumaroyl-CoA and feruloyl-CoA. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||
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EC | 1.3.99.41 | ||||||||||
Accepted name: | 3-(methylsulfanyl)propanoyl-CoA 2-dehydrogenase | ||||||||||
Reaction: | 3-(methylsulfanyl)propanoyl-CoA + acceptor = 3-(methylsulfanyl)acryloyl-CoA + reduced acceptor | ||||||||||
Other name(s): | dmdC (gene name) | ||||||||||
Systematic name: | 3-(methylsulfanyl)propanoyl-CoA:acceptor 2-oxidoreductase | ||||||||||
Comments: | The enzyme, found in marine bacteria, participates in a 3-(methylsulfanyl)propanoate degradation pathway. Based on similar enzymes, the in vivo electron acceptor is likely electron-transfer flavoprotein (ETF). | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||
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EC | 2.8.3.17 | ||||||||||
Accepted name: | 3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase | ||||||||||
Reaction: | (1) (E)-cinnamoyl-CoA + (R)-(phenyl)lactate = (E)-cinnamate + (R)-(phenyl)lactoyl-CoA (2) (E)-4-coumaroyl-CoA + (R)-3-(4-hydroxyphenyl)lactate = 4-coumarate + (R)-3-(4-hydroxyphenyl)lactoyl-CoA (3) 3-(indol-3-yl)acryloyl-CoA + (R)-3-(indol-3-yl)lactate = 3-(indol-3-yl)acrylate + (R)-3-(indol-3-yl)lactoyl-CoA |
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Other name(s): | FldA; cinnamoyl-CoA:phenyllactate CoA-transferase | ||||||||||
Systematic name: | 3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase | ||||||||||
Comments: | The enzyme, found in some amino acid-fermenting anaerobic bacteria, participates in the fermentation pathways of L-phenylalanine, L-tyrosine, and L-tryptophan. It forms a complex with EC 4.2.1.175, (R)-3-(aryl)lactoyl-CoA dehydratase. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 289682-21-9 | ||||||||||
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EC | 4.2.1.54 | ||||||||||
Accepted name: | lactoyl-CoA dehydratase | ||||||||||
Reaction: | (R)-lactoyl-CoA = acryloyl-CoA + H2O | ||||||||||
Other name(s): | lactoyl coenzyme A dehydratase; lactyl-coenzyme A dehydrase; lactyl CoA dehydratase; acrylyl coenzyme A hydratase; lactoyl-CoA hydro-lyase | ||||||||||
Systematic name: | (R)-lactoyl-CoA hydro-lyase (acryloyl-CoA-forming) | ||||||||||
Comments: | A bacterial enzyme that is involved in propanoate fermentation (also known as the acrylate pathway). | ||||||||||
Links to other databases: | BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, CAS registry number: 9031-12-3 | ||||||||||
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EC | 4.2.1.57 | ||||||||||
Accepted name: | isohexenylglutaconyl-CoA hydratase | ||||||||||
Reaction: | 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O | ||||||||||
Other name(s): | 3-hydroxy-3-isohexenylglutaryl-CoA-hydrolase; isohexenylglutaconyl coenzyme A hydratase; β-isohexenylglutaconyl-CoA-hydratase; 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase | ||||||||||
Systematic name: | 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA hydro-lyase [3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA-forming] | ||||||||||
Comments: | Also acts on dimethylacryloyl-CoA and farnesoyl-CoA. | ||||||||||
Links to other databases: | BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, CAS registry number: 37290-84-9 | ||||||||||
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EC | 4.2.1.116 | ||||||||||
Accepted name: | 3-hydroxypropionyl-CoA dehydratase | ||||||||||
Reaction: | 3-hydroxypropanoyl-CoA = acryloyl-CoA + H2O | ||||||||||
For diagram of the 3-hydroxypropanoate cycle, click here and for diagram of the 3-hydroxypropanoate/4-hydroxybutanoate cycle and dicarboxylate/4-hydroxybutanoate cycle in archaea, click here | |||||||||||
Glossary: | acryloyl-CoA = acrylyl-CoA 3-hydroxypropanoyl-CoA = 3-hydroxypropionyl-CoA |
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Other name(s): | 3-hydroxypropionyl-CoA hydro-lyase; 3-hydroxypropanoyl-CoA dehydratase | ||||||||||
Systematic name: | 3-hydroxypropanoyl-CoA hydro-lyase | ||||||||||
Comments: | Catalyses a step in the 3-hydroxypropanoate/4-hydroxybutanoate cycle, an autotrophic CO2 fixation pathway found in some thermoacidophilic archaea [1]. The enzyme from Metallosphaera sedula acts nearly equally as well on (S)-3-hydroxybutanoyl-CoA but not (R)-3-hydroxybutanoyl-CoA [2]. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||
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EC | 4.2.1.155 | ||||||||||
Accepted name: | (methylthio)acryloyl-CoA hydratase | ||||||||||
Reaction: | 3-(methylsulfanyl)acryloyl-CoA + 2 H2O = acetaldehyde + methanethiol + CoA + CO2 (overall reaction) (1a) 3-(methylsulfanyl)acryloyl-CoA + H2O = 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA (1b) 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA = 3-oxopropanoyl-CoA + methanethiol (1c) 3-oxopropanoyl-CoA + H2O = 3-oxopropanoate + CoA (1d) 3-oxopropanoate = acetaldehyde + CO2 |
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Glossary: | 3-(methylsulfanyl)acryloyl-CoA = 3-(methylsulfanyl)prop-2-enoyl-CoA | ||||||||||
Other name(s): | DmdD | ||||||||||
Systematic name: | 3-(methylsulfanyl)prop-2-enoyl-CoA hydro-lyase (acetaldehyde-forming) | ||||||||||
Comments: | The enzyme is involved in the degradation of 3-(dimethylsulfonio)propanoate, an osmolyte produced by marine phytoplankton. Isolated from the bacterium Ruegeria pomeroyi. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||
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EC | 4.2.1.175 | ||||||||||
Accepted name: | (R)-3-(aryl)lactoyl-CoA dehydratase | ||||||||||
Reaction: | (1) (R)-3-(phenyl)lactoyl-CoA = (E)-cinnamoyl-CoA + H2O (2) (R)-3-(4-hydroxyphenyl)lactoyl-CoA = (E)-4-coumaroyl-CoA + H2O (3) (R)-3-(indol-3-yl)lactoyl-CoA = 3-(indol-3-yl)acryloyl-CoA + H2O |
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Other name(s): | fldBC (gene names); (R)-phenyllactoyl-CoA dehydratase; aryllactyl-CoA dehydratase | ||||||||||
Systematic name: | (R)-3-(aryl)lactoyl-CoA hydro-lyase | ||||||||||
Comments: | The enzyme, found in some amino acid-fermenting anaerobic bacteria, participates in the fermentation pathways of L-phenylalanine, L-tyrosine, and L-tryptophan. It is a heterodimeric protein consisting of the FldB and FldC polypeptides, both of which contain an [4Fe-4S] cluster, and forms a complex with EC 2.8.3.17, 3-(aryl)acryloyl-CoA:(R)-3-(aryl)lactate CoA-transferase (FldA). In order to catalyse the reaction, the enzyme requires one high-energy electron that transiently reduces the electrophilic thiol ester carbonyl of the substrate to a nucleophilic ketyl radical anion, facilitating the elimination of the hydroxyl group. This electron, which is provided by by EC 5.6.1.9, (R)-2-hydroxyacyl-CoA dehydratase activating ATPase, needs to be supplied only once, before the first reaction takes place, as it is regenerated at the end of each reaction cycle. The enzyme acts on (R)-3-(aryl)lactoyl-CoAs produced by FldA, and regenerates the CoA donors used by that enzyme. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||
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EC | 4.3.1.6 | ||||||||||
Accepted name: | β-alanyl-CoA ammonia-lyase | ||||||||||
Reaction: | β-alanyl-CoA = acryloyl-CoA + NH3 | ||||||||||
Other name(s): | β-alanyl coenzyme A ammonia-lyase | ||||||||||
Systematic name: | β-alanyl-CoA ammonia-lyase (acryloyl-CoA-forming) | ||||||||||
Comments: | The reaction has only been demonstrated in the direction of addition of ammonia. | ||||||||||
Links to other databases: | BRENDA, EXPASY, GTD, KEGG, MetaCyc, CAS registry number: 9024-29-7 | ||||||||||
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